Nicotine is a synthetically produced chemical, people believe it is a dangerous substance, when in fact, the smoke and other chemicals in cigarettes are harmful. There is no chance of poisoning yourself by vaping nicotine, as we all know our limits, if vaping a too high nicotine strength it might make you feel a bit nauseous and give you a headache. Nicotine is great for the throat-hit, if you are vaping and not getting a satisfying hit, you might need to try a higher nicotine level.